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Vitrase (Ista Pharma): Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Vitrase (Ista Pharma) - General Information

Highly purified sheep hyaluronidase for administration by injection into the vitreous of the eye.

 

Pharmacology of Vitrase (Ista Pharma)

Vitrase (Ista Pharma) hydrolyzes hyaluronic acid and increase diffusion of injected drugs, thus facilitating their absorption. Vitrase (Ista Pharma) is used for enhancing absorption and distribution of other injected drugs.

 

Additional information about Vitrase (Ista Pharma)

Vitrase (Ista Pharma) Indication: For increase of absorption and distribution of other injected drugs and for rehydration Mechanism Of Action: Vitrase (Ista Pharma) is a spreading or diffusing substance. It increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Vitrase (Ista Pharma) hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Hyaluronidase Synonyms: Hyal-1; Hyaluronidase 1 precursor; Hyaluronidase PH-20; Sperm adhesion molecule 1; Sperm surface protein PH-20 Drug Category: Anesthetic Adjuvants; Permeabilizing Agents Drug Type: Biotech; Approved; Investigational Other Brand Names containing Hyaluronidase: Vitrase (Ista Pharma); Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Vitrase (Ista Pharma): Not Available Chemical IUPAC Name: Sheep hyaluronidase Chemical Formula: C2455H3775N617O704S21 Hyaluronidase on Wikipedia: https://en.wikipedia.org/wiki/Hyaluronidase Organisms Affected: Humans and other mammals